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Title

Summary Measures of Adherence Using Pill Counts in Two HIV Prevention Trials: The Need for Standardisation in Reporting.

Authors

Baisley K, Baeten JM, Hughes JP, Donnell DJ, Wang J, Hayes R, Jones DW, Celum C.

Network Affiliation

Other

Organization

 

Journal Name

AIDS Behav.

Publication Date

6/26/2013

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/23801018

Link to full-text

 

PMID

23801018

Abstract

​For trials of user-dependent HIV prevention products, accurate adherence measurements are essential to interpret and compare results across trials. We used pill count data from two recent HIV prevention trials of herpes simplex virus type 2 (HSV-2) suppression, to show that estimates of adherence vary substantially depending on assumptions that are made in analysing pill count data. We associate calculated adherence with biological markers of anti-HSV-2 activity. In both trials, calculated adherence varied considerably, depending on the summary measure used, and the handling of intervals with apparent 'over-adherence' (fewer pills returned than expected), and unreturned pills. Intervals of apparent over-adherence were associated with reduced antiviral effects on biological markers of herpes reactivation, indicating these are likely to represent periods of non-adherence. Our results demonstrate the clear need for standardisation in reporting of adherence data that are based on pill counts.

Keywords

 

Topic

Adherence

Attachments

Created at 6/28/2013 9:31 AM by Davis, Gregory P
Last modified at 6/28/2013 9:31 AM by Davis, Gregory P