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Title

Use of Antiretrovirals for HIV Prevention: What Do We Know and What Don't We Know?

Authors

Baeten JM, Grant R.

Network Affiliation

Other

Organization

 

Journal Name

Curr HIV/AIDS Rep.

Publication Date

3/1/2013

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/23494772

Link to full-text

 

PMID

 

Abstract

Pre-exposure prophylaxis (PrEP), in which HIV uninfected persons with ongoing HIV risk use antiretroviral medications as chemoprophylaxis against sexual HIV acquisition, is a promising new HIV prevention strategy. Proof-of-concept that PrEP, as oral or vaginal topical tenofovir-based products, protects against sexual HIV acquisition has been demonstrated in clinical trials conducted among men who have sex with men and heterosexual men and women. The degree of HIV protection in these trials was strongly related to the level of adherence to PrEP. Many questions are yet unanswered - including how to motivate uptake of and sustain adherence to PrEP for HIV prevention, how much PrEP use is enough to achieve HIV protection, and the potential of "next-generation" PrEP agents to improve on this effective technology.

Keywords

 

Topic

Adherence; Behavior; PrEP

Attachments

Created at 3/22/2013 11:15 AM by Davis, Gregory P
Last modified at 3/22/2013 11:15 AM by Davis, Gregory P