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Title

Social network based recruitment successfully reveals HIV-1 transmission networks among high risk individuals in El Salvador

Authors

AM Dennis, W. Murillo, F. de Maria Hernandez, et al.

Network Affiliation

Other

Organization

 

Journal Name

JAIDS

Publication Date

1/1/2013

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/?term=23364512

Link to full-text

 

PMID

 

Abstract

Abstract

OBJECTIVE:: HIV in Central America is concentrated among certain groups such as men who have sex with men (MSM) and female sex workers (FSW). We compared social recruitment chains and HIV transmission clusters from 699 MSM and 757 FSW to better understand factors contributing to ongoing HIV transmission in El Salvador. METHODS:: Phylogenies were reconstructed using pol sequences from 119 HIV-positive individuals recruited by respondent driven sampling (RDS) and compared to RDS chains in three cities in El Salvador. Transmission clusters with a mean pairwise genetic distance ≤0.015 and Bayesian posterior probabilities=1 were identified. Factors associated with cluster membership were evaluated among MSM. RESULTS:: Sequences from 34 (43%) MSM and 4 (10%) FSW grouped in 14 transmission clusters. Clusters were defined by risk group (12 MSM clusters) and geographic residence (only one spanned separate cities). In 4 MSM clusters (all n=2), individuals were also members of the same RDS chain but only 2 had members directly linked through recruitment. All large clusters (n≥3) spanned more than one RDS chain. Among MSM, factors independently associated with cluster membership included recent infection by BED assay (P=0.02), sex with stable male partners (P=0.02), and sex with ≥3 male partners in past year (P=0.04). CONCLUSIONS:: We found few HIV transmissions corresponding directly with the social recruitment. However, we identified clustering in nearly one half of MSM suggesting RDS recruitment was indirectly but successfully uncovering transmission networks, particularly among recent infections. Interrogating RDS chains with phylogenetic analyses may help refine methods for identifying transmission clusters.

Keywords

 

Topic

Behavior; MSM; Women

Attachments

Created at 2/22/2013 11:39 AM by Davis, Gregory P
Last modified at 2/22/2013 11:39 AM by Davis, Gregory P