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Title

Cytokine Profile in Genital Tract Secretions from Female Adolescents: Impact of HIV, HPV and other Sexually Transmitted Pathogens

Authors

 

Network Affiliation

Other

Organization

 

Journal Name

Journal of Infectious Diseases

Publication Date

3/1/2000

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed?term=10720516

Link to full-text

 

PMID

10720516

Abstract

Quantitative enzyme-linked immunosorbent assays were used to measure interleukin (IL)-2, IL-10, and IL-12 in cervical secretions from female adolescents with and without sexually transmitted infections. Compared with human immunodeficiency virus [HIV]-negative patients, HIV-positive patients had higher concentrations of IL-10 (118.2 pg/mL vs. 34.5 pg/mL; P=.002) and IL-12 (175.5 pg/mL vs. 85.1; P=.03). IL-2 concentrations were not statistically different. Furthermore, genital tract infections were predictors of IL-10 and IL-12 concentrations. Coinfection with HIV and human papillomavirus predicted the highest IL-10 concentrations; coinfection with HIV, human papillomavirus, and other sexually transmitted pathogens predicted the highest IL-12 concentrations. The data indicate that concomitant infection of the genital tract with HIV and other viral, bacterial, or protozoan pathogens influences the local concentrations of some immunoregulatory cytokines.

Keywords

 

Topic

Adolescents/Youth; Women

Attachments

Created at 3/30/2012 10:22 AM by Davis, Gregory P
Last modified at 3/30/2012 10:22 AM by Davis, Gregory P