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Title

Vitamin D status in adolescents and young adults with HIV infection

Authors

CB Stephensen, GS Marquis, LA Kruzich, et al.

Network Affiliation

Other

Organization

 

Journal Name

 

Publication Date

5/1/2006

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed?term=16685057

Link to full-text

 

PMID

 

Abstract

Abstract

BACKGROUND:

Vitamin D status affects immune function and thus may affect the progress of HIV infection.

OBJECTIVES:

Our goals were to assess vitamin D intake and status in subjects with HIV infection and in matched control subjects and to determine whether HIV infection was associated with vitamin D insufficiency.

DESIGN:

Plasma 25-hydroxyvitamin D [25(OH)D] concentrations and vitamin D intake were measured in a cross-sectional study of members of the Reaching for Excellence in Adolescent Health (REACH) cohort.

RESULTS:

The subjects were aged 14-23 y; 74% were female, and 72% were black. Mean (+/-SE) vitamin D intake from food was 30% greater (P = 0.023) in HIV-positive subjects (295 +/- 18 IU/d; n = 237) than in HIV-negative subjects (227 +/- 26 IU/d; n = 121). The prevalence of vitamin D supplement use was 29% (104 of 358 subjects) and did not differ significantly by HIV status (P = 0.87). Mean plasma 25(OH)D did not differ significantly (P = 0.62) between the HIV-positive (20.3 +/- 1.1 nmol/L; n = 238) and HIV-negative (19.3 +/- 1.7 nmol/L; n = 121) subjects, nor was HIV status a significant predictor of plasma 25(OH)D when multiple regression analysis was used to adjust for other variables. The prevalence of vitamin D insufficiency [plasma 25(OH)D < or = 37.5 nmol/L] in the subjects was 87% (312 of 359 subjects).

CONCLUSIONS:

HIV infection did not influence vitamin D status. The prevalence of vitamin D insufficiency in both HIV-positive and HIV-negative REACH subjects was high, perhaps because these disadvantaged, largely urban youth have limited sun exposure.

Keywords

 

Topic

Adolescents/Youth; Behavior; Women

Attachments

Created at 3/23/2012 10:33 AM by Davis, Gregory P
Last modified at 3/23/2012 10:33 AM by Davis, Gregory P