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Title

Pregnant Women's Access to PMTCT and ART Services in South Africa and Implications for Universal Antiretroviral Treatment

Authors

A. Hussain, D. Moodley, S. Naido, TM Esterhuizen

Network Affiliation

Other

Organization

 

Journal Name

PLoS One

Publication Date

12/5/2011

PubMed Search

 

Link to full-text

 

PMID

 

Abstract

Objectives: We describe pregnant womens’ access to PMTCT and HAART services and associated birth outcomes in South
Africa.
Methods: Women recuperating in postnatal wards of a referral hospital participated in an evaluation during February–May
2010 during which their maternity records were examined to describe their access to VCT, CD4 Counts, dual ART or HAART
during pregnancy.
Results: Of the 1609 women who participated in this evaluation, 39% (95%CI36.7–41.5%) tested HIV-positive during their
pregnancy. Of the HIV-positive women 2.9% did not have a CD4 count done and an additional 31.3% did not receive their
CD4 results. The majority (96.8%) of the HIV-positive women commenced dual ART at their first antenatal visit independent
of their CD4 result. During February–May 2010, 48.0% of the women who had a CD4 result were eligible for HAART
(CD4,200 cells/mm3) and 29.1% of these initiated HAART during pregnancy. Under the current South African PMTCT
guidelines 71.1% (95%CI66.4–75.4%) of HIV positive pregnant women could be eligible for HAART (CD4,350 cells/mm3).
There were significantly more preterm births among HIV-positive women (p = 0.01) and women who received HAART were
no more at risk of preterm deliveries (AOR 0.73;95%CI0.39–1.36;p = 0.2) as compared to women who received dual ART. Nine
(2.4%; 95%CI1.1–4.5%) HIV exposed infants were confirmed HIV infected at birth. The in-utero transmission rate was highest
among women who required HAART but did not initiate treatment (8.5%) compared to 2.7% and 0.4% among women who
received HAART and women who were not eligible for HAART and received PMTCT prophylaxis respectively.
Conclusion: In this urban South African community the antenatal HIV prevalence remains high (39%) and timeous access to
CD4 results during pregnancy is limited. Under the current South African guidelines, and assuming that access to CD4
results has improved, more than 70% of HIV-positive pregnant women in this community would be requiring HAART.

Keywords

 

Topic

Adherence; Behavior; Women

Attachments

Created at 12/9/2011 11:18 AM by Davis, Gregory P
Last modified at 12/9/2011 11:18 AM by Davis, Gregory P