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Title

Behavioral Considerations for Engaging Youth in HIV Research

Authors

Hosek SG, Zimet GD

Network Affiliation

Other

Organization

 

Journal Name

JAIDS

Publication Date

7/1/2010

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/20571420

Link to full-text

 

PMID

20571420

Abstract

From both scientific and ethical perspectives, it is important that youth be enrolled in biomedical HIV prevention clinical trials. At the same time, adolescents, as minors, are considered a vulnerable population requiring particular attention to the reduction of potential harm associated with participation in such trials. In this article, we review the evidence supporting enrollment of youth in HIV clinical trials, including data on HIV infection rates, sexual behavior, and cognitive, psychosocial, and neurophysiological development. Next, we address the potential risks associated with clinical trial participation, with a focus on the concept of preventive misconception, the tendencies to (1) overestimate the probability of assignment to the experimental condition, as opposed to the placebo, and (2) assume that the experimental intervention is efficacious. Finally, we discuss targeted interventions to reduce preventive misconception and the importance of developing and testing adolescent-friendly risk-reduction interventions that are tailored to the structure and time frame of a biomedical HIV prevention clinical trial. The very issues that make inclusion of youth in HIV prevention clinical trials necessary also demand that particularly intensive efforts be made to protect participating minors from the harm that could accrue from a clinical trial.

 

Keywords

 

Topic

Recruitment & Retention; Youth

Attachments

Created at 11/18/2010 11:12 AM by Mooney, Jessica L
Last modified at 11/19/2010 10:44 AM by Mooney, Jessica L