Skip Ribbon Commands
Skip to main content

Title

Real-Time Adherence Monitoring for HIV Antiretroviral Therapy

Authors

Haberer JE, Kahane J, Kigozi I

Network Affiliation

Other

Organization

 

Journal Name

AIDS Behavior

Publication Date

12/1/2010

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/20809380

Link to full-text

http://www.springerlink.com/content/4012134j345l2825/

PMID

20809380

Abstract

Current adherence assessments typically detect missed doses long after they occur. Real-time, wireless monitoring strategies for antiretroviral therapy may provide novel opportunities to proactively prevent virologic rebound and treatment failure. Wisepill, a wireless pill container that transmits a cellular signal when opened, was pilot tested in ten Ugandan individuals for 6 months. Adherence levels measured by Wisepill, unannounced pill counts, and self-report were compared with each other, prior standard electronic monitoring, and HIV RNA. Wisepill data was initially limited by battery life and signal transmission interruptions. Following device improvements, continuous data was achieved with median (interquartile range) adherence levels of 93% (87–97%) by Wisepill, 100% (99–100%) by unannounced pill count, 100% (100–100%) by self-report, and 92% (79–98%) by prior standard electronic monitoring. Four individuals developed transient, low-level viremia. After overcoming technical challenges, real-time adherence monitoring is feasible for resource-limited settings and may detect suboptimal adherence prior to viral rebound.

 

Keywords

 

Topic

Adherence

Attachments

Created at 11/18/2010 11:04 AM by Mooney, Jessica L
Last modified at 11/19/2010 10:44 AM by Mooney, Jessica L