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Title

"Tell Juliana": Acceptability of the Candidate Microbicide VivaGel and Two Placebo Gels Among Ethinically Diverse, Sexually Active Young Women Participating in a Phase 1 Microbicide Study

Authors

Alex Carballo-Dieguez, Rebecca Giguere, Curtis Dolezal et al.

Network Affiliation

Other

Organization

 

Journal Name

AIDS Behav.

Publication Date

8/24/2011

PubMed Search

 

Link to full-text

 

PMID

 

Abstract

This study assess acceptability of the candidate microbicide VivaGel and two placebo gels among 61 sexually active young US and Puerto Rican women at three sites. Participants were randomly assigned to use on of the gels twice per day for 14 days. At trial completion, 59% of the women in the VivaGel group reported being likely to use the gel in the future, whereas 23% were unlikely to use it and 18% were undecided. Participants reported problems with all three gels, including the "universal" placebo containing hydroxyethyl cellulose (HEC). Te most frequent complaitns were leakage, interfenrece with sexual behavior and decresed sexual satisfaction. Some of the complaints are not new but remain unresolved. Women's perceived risk of HIV infection may determine whether the gels are used. Users also may want a choice of viscosity. Poor acceptability of vaginal microbicide formulations may result in poor adherence to gel use during efficacy trials and compromise validity of results.

Keywords

 

Topic

Adherence; Behavior; Women

Attachments

Created at 9/2/2011 1:26 PM by Davis, Gregory P
Last modified at 9/2/2011 1:26 PM by Davis, Gregory P