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Title

Trauma, dissociation, and antiretroviral adherence among persons living with HIV/AIDS

Authors

Keuroghlian AS, Kamen CS, Neri E

Network Affiliation

Other

Organization

 

Journal Name

Journal of Psychiatric Research

Publication Date

7/1/2011

PubMed Search

 

Link to full-text

http://www.ncbi.nlm.nih.gov/pubmed?term=Trauma%2C%20dissociation%2C%20and%20antiretroviral%20adherence%20among%20persons%20living%20with%20HIV%2FAIDS

PMID

21636097

Abstract

BACKGROUND:

There are approximately 1,000,000 persons living with HIV/AIDS (PLH) in the United States; to reduce rates of new infection and curb disease progression, adherence to HIV medication among PLH is critical. Despite elevated trauma rates in PLH, no studies to date have investigated the relationship between dissociation, a specific symptom of trauma, and HIV medication adherence. We hypothesized that Post-Traumatic Stress Disorder (PTSD) symptoms would be associated with lower adherence, and that dissociation would moderate this relationship.

METHODS:

Forty-three individuals with HIV were recruited from community-based clinics to participate in a cross-sectional study. The relationship of trauma, dissociation, and their interaction to the probability of antiretroviral adherence was assessed using a hierarchical binary logistic regression analysis.

RESULTS:

Among 38 eligible participants, greater PTSD was associated with lower odds of adherence (OR = .92, p < .05). Dissociation moderated the effect of PTSD on adherence, resulting in lower odds of adherence (OR = .95, p < .05). PTSD symptoms were significantly associated with lower odds of adherence in individuals reporting high levels of dissociation (OR = .86, p < .05) but not in those reporting low levels of dissociation (OR = 1.02, p > .05).

CONCLUSIONS:

This is the first study to demonstrate a relationship between dissociation and medication adherence. Findings are discussed in the context of clinical management of PLH with trauma histories and the need for interventions targeting dissociative symptomatology to optimize adherence.

Keywords

 

Topic

Adherence

Attachments

Created at 6/24/2011 1:38 PM by Mooney, Jessica L
Last modified at 6/24/2011 1:38 PM by Mooney, Jessica L