The purpose of this exploratory study was to examine personal characteristics, socio-environmental conditions, and motivational factors that potentially influence HIV vaccine research community engagement. Specifically, the study identified predictive aspects that may aid in future community program development on HIV vaccine issues. A cross-sectional survey consisting of evaluative measures, demographics, social interaction, and health information-seeking behaviors was conducted. Participants were a diverse group of 452 adults (≥18 years) at HIV vaccine awareness-building and community education gatherings in Atlanta. The sample included large numbers of women (n = 251) and minorities (n = 224). In multivariate analysis, the overall logistic regression model was significant, with a resulting coefficient of determination (Nagelkerke R 2) of .505. Highly significant factors included an excellent activity/event rating (log odds β = 4.521, P < .001), White race (β = −.835, P = .005), greater educational attainment (β = .725, P = .011), travel distance (β = 1.186, P = .002), and excellent perception of the study site (β = 2.131, P < .001). Subgroup analyses by gender and race revealed similar findings. These data demonstrate the importance of building a favorable study site image and gaining familiarity in the community to aid in the promotion of HIV vaccine research on an ongoing basis.