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Title

Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV-infected individuals

Authors

Lin K, Taylor MJ, Heaton R

Network Affiliation

Other

Organization

CHARTER Group

Journal Name

Journal of Clinical and Experimental Neuropsychology

Publication Date

1/10/2011

PubMed Search

http://www.ncbi.nlm.nih.gov/pubmed/21229435

Link to full-text

 

PMID

21229435

Abstract

We explored the possible augmenting effect of traumatic brain injury (TBI) history on HIV (human immunodeficiency virus) associated neurocognitive complications. HIV-infected participants with self-reported history of definite TBI were compared to HIV patients without TBI history. Groups were equated for relevant demographic and HIV-associated characteristics. The TBI group evidenced significantly greater deficits in executive functioning and working memory. N-acetylaspartate, a putative marker of neuronal integrity, was significantly lower in the frontal gray matter and basal ganglia brain regions of the TBI group. Together, these results suggest an additional brain impact of TBI over that from HIV alone. One clinical implication is that HIV patients with TBI history may need to be monitored more closely for increased risk of HIV-associated neurocognitive disorder signs or symptoms.

Keywords

 

Topic

Neurocognitive Assessments; CHARTER Group

Attachments

Created at 2/24/2011 2:29 PM by Mooney, Jessica L
Last modified at 2/24/2011 2:29 PM by Mooney, Jessica L