​The Division of AIDS (DAIDS) is beginning the implementation of an evaluation system for DAIDS and its HIV/AIDS clinical research networks. Federal statutory and NIH mandates require DAIDS to conduct evaluations of its operations and programs. This evaluation system has been designed to support the Division and its investigators in a cross-network evaluation that includes identifying critical success factors, defining and implementing best practices, and assessing progress towards achieving the mutual goals of scientific excellence, integration of therapeutics and prevention research, efficient use of resources and effective collaboration. Evaluation data from this system, in conjunction with expert scientific review, may provide important feedback and will enhance DAIDS and its networks as they evolve. The scope of the evaluation of the DAIDS HIV clinical research enterprise includes DAIDS itself, the DAIDS-funded clinical trials networks and sites, and the HIV/AIDS Network Coordination office (HANC).